Article

Inhibition of let-7b-5p contributes to an anti-tumorigenic macrophage phenotype through the SOCS1/STAT pathway in prostate cancer

2020-09-18

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>Dysfunction of microRNAs (miRNAs) is a major cause of aberrant expression of inflammatory cytokines and contributes to macrophage polarization. Proinflammatory M1 macrophages promote T helper (Th) 1 responses and show tumoricidal activity, whereas M2 macrophages display regulatory functions in tissue repair and remodeling and promote Th2 immune responses. Previous...

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Literature Corpus work: 6d7611cc-68ea-5c3f-8a4d-d955302056c8
DOI: 10.21203/rs.3.rs-42696/v2

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