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Article

Subversion of infiltrating prostate macrophages to a mixed immunosuppressive tumor-associated macrophage phenotype.

Clinical and translational medicine - 1 Jan 2022

Boibessot Clovis, Molina Oscar, Lachance Gabriel, Tav Christophe, Champagne Audrey, Neveu Bertrand, Pelletier Jean-François, Pouliot Frédéric, Fradet Vincent, Bilodeau Steve, Fradet Yves, Bergeron Alain, Toren Paul

Abstract excerpt

Tumor-associated macrophages (TAMs) support tumor progression within the tumor microenvironment (TME). Many questions remain as to the origin, development, and function of TAMs within the prostate TME. Evaluation of TAMs in prostate cancer (PCa) patients identified the immunosuppressive TAM marker CD163 in adjacent normal epithelium as an independent predictor of metastases or PCa death. Flow cytometry analyses...

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Identifiers

PMID: 35075795
DOI: 10.1002/ctm2.581
PMCID: PMC8786699

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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