Article

Let-7d inhibits intratumoral macrophage M2 polarization and subsequent tumor angiogenesis by targeting IL-13 and IL-10

2020-05-18

Abstract excerpt

<h4>Background: </h4> The microRNA let-7d has been reported to be a tumor suppressor in many types of cancer, including renal cell carcinoma (RCC). Tumor-associated macrophages are M2-polarized macrophages that can enhance tumor growth and angiogenesis in many human cancers. However, the role of let-7d in TAM-associated RCC tumor progression remains elusive. <h4>Methods: </h4>: Human macrophage cell line THP-1 cel...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a8aa1c77-01c7-5e7d-a5f8-29a3286439ed
DOI: 10.21203/rs.3.rs-27516/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Let-7d inhibits intratumoral macrophage M2 polarization and subsequent tumor angiogenesis by targeting IL-13 and IL-10DOI 10.21203/rs.3.rs-27516/v1Read

miRNA let-7b modulates macrophage polarization and enhances tumor-associated macrophages to promote angiogenesis and mobility in prostate cancer.Semantic proximity Read

M2 macrophages contribute to cell proliferation and migration of breast cancerSemantic proximity Read

Inhibition of let-7b-5p contributes to an anti-tumorigenic macrophage phenotype through the SOCS1/STAT pathway in prostate cancerSemantic proximity Read

MicroRNA let-7c regulates macrophage polarization.Semantic proximity Read

Dynamic macrophage polarization-specific miRNA patterns reveal increased soluble VEGF receptor 1 by miR-125a-5p inhibition.Semantic proximity Read

MicroRNA-19a-3p inhibits breast cancer progression and metastasis by inducing macrophage polarization through downregulated expression of Fra-1 proto-oncogene.Semantic proximity Read

IL-12 Regulates B7-H1 Expression in Ovarian Cancer-associated Macrophages by Effects on NF-κB SignallingSemantic proximity Read

Ovarian Cancer Cell-Derived Exosomal miR-205 Promotes M2 Macrophage Polarization and Ovarian Cancer Cell Metastasis By Activating The AKT/mTOR Signalling PathwaySemantic proximity Read

IL-27 neutralization enhances macrophage polarization and improves immune checkpoint efficacySemantic proximity Read

Gefitinib inhibits M2-like polarization of tumor-associated macrophages in Lewis lung cancer by targeting the STAT6 signaling pathway.Semantic proximity Read

LncRNA MYU Facilitates Angiogenesis in HUVECs under Hypoxia by Functioning as a ceRNA for miR-23a-3pSemantic proximity Read

Nucleotide receptor P2X7/STAT6 pathway regulates macrophage M2 polarization and its application in CAR-T immunotherapySemantic proximity Read