Article
miRNA let-7b modulates macrophage polarization and enhances tumor-associated macrophages to promote angiogenesis and mobility in prostate cancer.
Scientific reports - 9 May 2016
Wang Zhigang, Xu Lu, Hu Yinying, Huang Yanqin, Zhang Yujuan, Zheng Xiufen, Wang Shanshan, Wang Yifan, Yu Yanrong, Zhang Meng, Yuan Keng, Min Weiping
Abstract excerpt
Macrophage polarization is a highly plastic physiological process that responds to a variety of environmental factors by changing macrophage phenotype and function. Tumor-associated macrophages (TAMs) are generally recognized as promoting tumor progression. As universal regulators, microRNAs (miRNAs) are functionally involved in numerous critical cellular processes including macrophage polarization. Let-7b, a...
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