Article

CXCR4 regulates macrophage M1 polarization by altering glycolysis to promote prostate fibrosis

2024-07-04

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold> CXCR4 (C-X-C receptor 4) is widely considered to be a highly conserved G protein-coupled receptor, widely involved in the pathophysiological processes in the human body, including fibrosis. However, its role in regulating macrophage-related inflammation in the fibrotic process of prostatitis has not been confirmed. Here, we aim to describe the role of CXCR4 in mo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9471c790-6c90-5a22-aa13-970c242a8089
DOI: 10.21203/rs.3.rs-4592373/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CXCR4 regulates macrophage M1 polarization by altering glycolysis to promote prostate fibrosisDOI 10.21203/rs.3.rs-4592373/v1Read

Tumor-associated macrophage enhances PD-L1-mediated immune escape of bladder cancer through PKM2 dimer/STAT3 complex nuclear translocationSemantic proximity Read

Emerging Importance of Chemokine Receptor CXCR4 and Its Ligand in Liver DiseaseSemantic proximity Read

A Comprehensive High-Efficiency Protocol for Isolation, Culture, Polarization, and Glycolytic Characterization of Bone Marrow-Derived Macrophages.Semantic proximity Read

Targeting CCR1-mediated macrophage phenotypic switching to alleviate bladder pain and urinary dysfunction in interstitial cystitis.Semantic proximity Read

Glucose Metabolism Mediates Feedback Control of Innate Immune Signaling in Human MacrophagesSemantic proximity Read

Pyruvate kinase M1 suppresses development and progression of prostate adenocarcinomaSemantic proximity Read

The relationship between immune cells and prostate cancer, and the mediating role of metabolites: a Mendelian randomization studySemantic proximity Read

Inhibition of let-7b-5p contributes to an anti-tumorigenic macrophage phenotype through the SOCS1/STAT pathway in prostate cancerSemantic proximity Read

The PI3K-Akt-CCND2 axis orchestrates macrophage M1 polarization through metabolic reprogramming: mechanistic and therapeutic insightsSemantic proximity Read

Subversion of infiltrating prostate macrophages to a mixed immunosuppressive tumor-associated macrophage phenotype.Semantic proximity Read

CXCR3 antagonist AMG487 ameliorates experimental autoimmune prostatitis by diminishing Th1 cell differentiation and inhibiting macrophage M1 phenotypic activation.Semantic proximity Read

The glycolysis/HIF-1α axis defines the inflammatory role of IL-4-primed 2 macrophagesSemantic proximity Read