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Article

Macrophage-derived cholesterol contributes to therapeutic resistance in prostate cancer

2021-03-24

Abstract excerpt

Tumor-associated macrophages are key immune cells associated with cancer progression. Here we sought to determine the role of macrophages in castration-resistant prostate cancer (CRPC) using a syngeneic model that reflected the mutational landscape of the disease. A transcriptomic analysis of CRPC tumors following macrophage depletion revealed lower molecular signatures for steroid and bile acid synthesis, indicat...

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Identifiers and source

Literature Corpus work
6574f48c-41e1-56ca-86eb-b9a49eeb4004
DOI
10.1101/2021.03.24.436480
Open publication

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Macrophage-derived cholesterol contributes to therapeutic resistance in prostate cancerDOI 10.1101/2021.03.24.436480
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