Article
Targeting interleukin 4 receptor alpha on tumor-associated macrophages reduces the pro-tumor macrophage phenotype.
Neoplasia (New York, N.Y.) - 1 Oct 2022
de Groot Amber E, Myers Kayla V, Krueger Timothy E G, Brennen W Nathaniel, Amend Sarah R, Pienta Kenneth J
Abstract excerpt
Tumor-associated macrophages (TAMs) are an abundant tumor-promoting cell type in the tumor microenvironment (TME). Most TAMs exhibit a pro-tumor M2-like phenotype supportive of tumor growth, immune evasion, and metastasis. IL-4 and IL-13 are major cytokines that polarize macrophages to an M2 subset and share a common receptor, IL-4 receptor alpha (IL-4R alpha). Treatment of human ex vivo polarized M2 macrophages...
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