Article
MicroRNA let-7c regulates macrophage polarization.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2013
Banerjee Sami, Xie Na, Cui Huachun, Tan Zheng, Yang Shanzhong, Icyuz Mert, Abraham Edward, Liu Gang
Abstract excerpt
Macrophages demonstrate a high level of plasticity, with the ability to undergo dynamic transition between M1 and M2 polarized phenotypes. The role of microRNAs (miRNAs) in regulating macrophage polarization has been largely undefined. In this study, we found that miRNA let-7c is expressed at a higher level in M-BMM (M2 macrophages) than in GM-BMM (M1 macrophages). let-7c levels are also greater in alveolar...
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