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Machine perfusion and single-cell spatial transcriptome mapping identifies novel immune escape mechanisms in colorectal cancer liver metastasis

2025-12-11

Abstract excerpt

Liver metastasis is the terminal stage of colorectal cancer. Immune checkpoint blockade (ICB) has heralded remarkable clinical success across a range of cancer types, but with limited efficacy in replacement-type colorectal liver metastasis (CRLM), the most common and lethal histological subtype. Using a novel human normothermic perfusion model, we demonstrate for the first time, that T-cells preferentially extrav...

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Literature Corpus work
6d6a0d4f-c271-51ad-9a93-0200402fea12
DOI
10.64898/2025.12.09.693114
Open publication

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