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Article

A Paradoxical Tumor Antigen Specific Response in the Liver

2024-09-24

Abstract excerpt

Functional tumor-specific CD8+ T cells are essential for an effective anti-tumor immune response and the efficacy of immune checkpoint inhibitor therapy. In comparison to other organ sites, we found higher numbers of tumor-specific CD8+ T cells in primary, metastatic liver tumors in murine tumor models. Despite their abundance, CD8+ T cells in the liver displayed an exhausted phenotype. Depletion of CD8+ T cells s...

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Literature Corpus work
627a3f1a-0762-5f1d-a558-3bd748ce6e67
DOI
10.1101/2024.09.19.614002
Open publication

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A Paradoxical Tumor Antigen Specific Response in the LiverDOI 10.1101/2024.09.19.614002
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