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Single-cell transcriptomic analysis reveals dynamic changes in the liver microenvironment during colorectal cancer metastatic progression

16 Mar 2025

Abstract excerpt

BACKGROUND: Metastasis is a leading cause of cancer-related deaths, with the liver being the most frequent site of metastasis in colorectal cancer. Previous studies have predominantly focused on the influence of the primary tumor itself on metastasis, with relatively limited research examining the changes within target organs. METHODS: Using an orthotopic mouse model of colorectal cancer, single-cell sequencing...

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PMID: 40091048
DOI: 10.1186/s12967-025-06351-3

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