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Spatial Transcriptomics Reveals Stromal-Partitioned Growth in Primary Colorectal Cancer and Host-Permeated Architecture in Liver Metastases

2026-02-12

Abstract excerpt

<title>Abstract</title> <p>The spatial organisation of the tumour microenvironment plays a central role in shaping immune engagement and tumour progression, yet how spatial principles differ between primary colorectal cancer and metastatic disease remains incompletely defined. Spatial transcriptomics (10x Visium) was integrated with cell-type deconvolution and transcriptional pathway enrichment to characterise tu...

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Literature Corpus work
f4ea8cb1-2622-53d1-910e-0bc8e835b402
DOI
10.21203/rs.3.rs-8852518/v1
Open publication

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Spatial Transcriptomics Reveals Stromal-Partitioned Growth in Primary Colorectal Cancer and Host-Permeated Architecture in Liver MetastasesDOI 10.21203/rs.3.rs-8852518/v1
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