Back to search

Article

Spatially Resolved Transcriptomics Deconvolutes Histological Prognostic Subgroups in Patients with Colorectal Cancer and Synchronous Liver Metastases

2022-09-22

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Patients demonstrating strong immune responses to primary colorectal cancer (CRC) have a survival benefit following surgery, while those with predominantly stromal microenvironments do poorly. Biomarkers to identify patients with colorectal cancer liver metastases (CRLM) who have good prognosis following surgery for oligometastatic disease remain elusive. The aim of this stu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
dab66cf0-1ef3-57df-8aee-f7d3ab2646c6
DOI
10.1101/2022.09.21.508569
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Spatially Resolved Transcriptomics Deconvolutes Histological Prognostic Subgroups in Patients with Colorectal Cancer and Synchronous Liver MetastasesDOI 10.1101/2022.09.21.508569
Spatial Transcriptomics Reveals Stromal-Partitioned Growth in Primary Colorectal Cancer and Host-Permeated Architecture in Liver MetastasesSemantic proximity
Transcriptomic and immunophenotypic profiling reveals molecular and immunological hallmarks of colorectal cancer tumourigenesisSemantic proximity
High-Resolution Spatial Proteomics Characterises Colorectal Cancer Consensus Molecular SubtypesSemantic proximity
A Single-Cell Atlas of Liver Metastases of Colorectal Cancer Reveals the Reprogramming of the Tumor Microenvironment in Response to Preoperative ChemotherapySemantic proximity
Identification of Spatial Proteomic Signatures of Colon Tumor Metastasis: A Digital Spatial Profiling ApproachSemantic proximity
Revisiting the immune microenvironment of human colorectal cancer in the era of single-cell and spatial omicsSemantic proximity
Spatial and single‐cell transcriptomic analysis reveals fibroblasts dependent immune environment in colorectal cancerSemantic proximity
Comprehensive characterization of tumor microenvironment in colorectal cancer via histopathology-molecular analysisSemantic proximity
INSIGHT: Spatially resolved survival modelling from routine histology crosslinked with molecular profiling reveals prognostic epithelial-immune axes in stage II/III colorectal cancerSemantic proximity
Transcriptomics and proteomics reveal distinct biology for lymph node metastases and tumour deposits in colorectal cancerSemantic proximity
Spatially resolved C1QC+ macrophage-CD4+ T cell niche in colorectal cancer microenvironment: implications for immunotherapy responseSemantic proximity
High-definition spatial transcriptomic profiling of immune cell populations in colorectal cancerSemantic proximity
Select a neighboring publication to make it the new centre.