Article

An integrated single-cell atlas of checkpoint inhibitor-induced liver injury links shared liver-tumour CD8+ T cell clones to cytotoxicity and macrophage crosstalks

2026-05-04

Abstract excerpt

<h4>ABSTRACT</h4> Immune checkpoint inhibitors (ICIs) have transformed cancer therapy, but they can also induce immune-related adverse events (irAEs). Checkpoint inhibitor-induced liver injury (ChILI) is among the most frequent irAEs, yet its pathophysiology remains poorly understood. Here, we assembled a cohort of liver biopsies from cancer patients with ChILI and used a multi-modal analysis integrating single-c...

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Literature Corpus work: 7a4d5ef6-e21d-53dc-a608-9abb7808ff3d
DOI: 10.64898/2026.04.27.26351449

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An integrated single-cell atlas of checkpoint inhibitor-induced liver injury links shared liver-tumour CD8+ T cell clones to cytotoxicity and macrophage crosstalksDOI 10.64898/2026.04.27.26351449Read

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