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Article

Topography of cancer-associated immune cells in human solid tumors.

eLife - 4 Sept 2018

Kather Jakob Nikolas, Suarez-Carmona Meggy, Charoentong Pornpimol, Weis Cleo-Aron, Hirsch Daniela, Bankhead Peter, Horning Marcel, Ferber Dyke, Kel Ivan, Herpel Esther, Schott Sarah, Zörnig Inka, Utikal Jochen, Marx Alexander, Gaiser Timo, Brenner Herrmann, Chang-Claude Jenny, Hoffmeister Michael, Jäger Dirk, Halama Niels

Abstract excerpt

Lymphoid and myeloid cells are abundant in the tumor microenvironment, can be quantified by immunohistochemistry and shape the disease course of human solid tumors. Yet, there is no comprehensive understanding of spatial immune infiltration patterns ('topography') across cancer entities and across various immune cell types. In this study, we systematically measure the topography of multiple immune cell types in...

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Identifiers

PMID: 30179157
DOI: 10.7554/eLife.36967
PMCID: PMC6133554

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