Article

Alzheimer<sup>’</sup>s-associated inflammatory alterations mediate tau-associated neurodegeneration in limbic and temporal regions across clinical variants of Alzheimer<sup>’</sup>s disease

2024-11-04

Abstract excerpt

<h4>Objectives</h4> Microglia monitor and respond to the brain ’ s microenvironment to maintain homeostasis. However, in Alzheimer ’ s disease and related dementias (ADRD), microglia may contribute to pathology. We hypothesized that AD-related inflammatory changes, measured with TSPO PET, would be locally associated with amyloid, tau, and neurodegeneration, and influence key pathways among them. <h4>Methods</h4> P...

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Literature Corpus work: 5742bca7-617b-5925-8559-8195f183ec03
DOI: 10.1101/2024.11.01.24316493

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