Article

Thiamine pyrophosphokinase deficiency induces Alzheimer’s pathology

2020-06-11

Abstract excerpt

<h4>Background</h4> Thiamine diphosphate (TDP) reduction plays an important role in cerebral glucose hypometabolism, the neurodegenerative indicator, in Alzheimer’s disease (AD). The mechanism underlying TDP reduction remains elusive. Thus, it is critical to define the mechanism and its effect on neurodegeneration, the pathological basis of the disease occurrence and progression. <h4>Methods</h4> The mRNA levels...

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Literature Corpus work: 8e5fa2dc-1022-50c3-aade-c004fc1279cb
DOI: 10.1101/2020.06.09.141358

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