Article

The mutational landscape of <i>EGFR-</i> , <i>MYC-</i> , and <i>Kras-</i> driven genetically-engineered mouse models of lung adenocarcinoma

2016-04-11

Abstract excerpt

Genetically-engineered mouse models (GEMMs) of cancer are increasingly being utilized to assess putative driver mutations identified by large scale sequencing of human cancer genomes. In order to accurately interpret experiments that introduce additional mutations, an understanding of the somatic genetic profile and evolution of GEMM tumors is necessary. Here, we performed whole exome sequencing of tumors from thr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6d4d1ef1-db39-586d-b4f0-9a243488f2a7
DOI: 10.1101/048058

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The mutational landscape of <i>EGFR-</i> , <i>MYC-</i> , and <i>Kras-</i> driven genetically-engineered mouse models of lung adenocarcinomaDOI 10.1101/048058Read

Mutational landscape of EGFR-, MYC-, and Kras-driven genetically engineered mouse models of lung adenocarcinoma.Semantic proximity Read

Kras mutant genetically engineered mouse models of human cancers are genomically heterogeneous.Semantic proximity Read

Genetic determinants of <i>EGFR</i> -Driven Lung Cancer Growth and Therapeutic Response <i>In Vivo</i>Semantic proximity Read

The mutational landscapes of genetic and chemical models of Kras-driven lung cancer.Semantic proximity Read

Mouse models in the era of large human tumour sequencing studies.Semantic proximity Read

Cross-species analysis of genetically engineered mouse models of MAPK-driven colorectal cancer identifies hallmarks of the human disease.Semantic proximity Read

Development and Application of MiMouse, a Comprehensive Genomic Profiling Panel for Credentialing Mouse Tumor Models.Semantic proximity Read

Germline mutations and developmental mosaicism underlying<i>EGFR</i>-mutant lung cancerSemantic proximity Read

Somatic mutations in murine models of leukemia and lymphoma: Disease specificity and clinical relevance.Semantic proximity Read

A Functional Taxonomy of Tumor Suppression in Oncogenic KRAS–Driven Lung CancerSemantic proximity Read

Genetic background sets the trajectory of cancer evolutionSemantic proximity Read

Genetically Engineered Mouse Models: Closing the Gap between Preclinical Data and Trial OutcomesSemantic proximity Read