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Article

Development and Application of MiMouse, a Comprehensive Genomic Profiling Panel for Credentialing Mouse Tumor Models.

Cancer research communications - 1 Oct 2025

Hu Kevin, Liu Chia-Jen, Qin Zhaoping, Udager Aaron M, Cieslik Marcin P, Tomlins Scott A

Abstract excerpt

Despite shared genetic driver alterations and histology, the genomic fidelity of most mouse tumor models, including those genetically engineered (GEMM), to their human counterparts is unknown. In this study, we developed MiMouse, a mouse comprehensive genomic profiling panel for high-throughput credentialing applicable to routine formalin-fixed, paraffin-embedded tumors. Through simulation/validation, we focused...

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Identifiers

PMID: 41051921
DOI: 10.1158/2767-9764.CRC-25-0279
PMCID: PMC12569591

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