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Article

Cross-species analysis of genetically engineered mouse models of MAPK-driven colorectal cancer identifies hallmarks of the human disease.

Disease models & mechanisms - 1 Jun 2014

Belmont Peter J, Budinska Eva, Jiang Ping, Sinnamon Mark J, Coffee Erin, Roper Jatin, Xie Tao, Rejto Paul A, Derkits Sahra, Sansom Owen J, Delorenzi Mauro, Tejpar Sabine, Hung Kenneth E, Martin Eric S

Abstract excerpt

Effective treatment options for advanced colorectal cancer (CRC) are limited, survival rates are poor and this disease continues to be a leading cause of cancer-related deaths worldwide. Despite being a highly heterogeneous disease, a large subset of individuals with sporadic CRC typically harbor relatively few established 'driver' lesions. Here, we describe a collection of genetically engineered mouse models...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24742783
DOI: 10.1242/dmm.013904
PMCID: PMC4036469

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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