Somatic mutations in murine models of leukemia and lymphoma: Disease specificity and clinical relevance.

Abstract excerpt

Malignant transformation is a multistep process that is dictated by the acquisition of multiple genomic aberrations that provide growth and survival advantage. During the post genomic era, high throughput genomic sequencing has advanced exponentially, leading to identification of countless cancer associated mutations with potential for targeted therapy. Mouse models of cancer serve as excellent tools to examine...

Topics

• Animals
• Disease Models, Animal
• Humans
• Leukemia
• Lymphoma
• Mice
• Mutation