Article
Mutational landscape of EGFR-, MYC-, and Kras-driven genetically engineered mouse models of lung adenocarcinoma.
Proceedings of the National Academy of Sciences of the United States of America - 18 Oct 2016
McFadden David G, Politi Katerina, Bhutkar Arjun, Chen Frances K, Song Xiaoling, Pirun Mono, Santiago Philip M, Kim-Kiselak Caroline, Platt James T, Lee Emily, Hodges Emily, Rosebrock Adam P, Bronson Roderick T, Socci Nicholas D, Hannon Gregory J, Jacks Tyler, Varmus Harold
Abstract excerpt
Genetically engineered mouse models (GEMMs) of cancer are increasingly being used to assess putative driver mutations identified by large-scale sequencing of human cancer genomes. To accurately interpret experiments that introduce additional mutations, an understanding of the somatic genetic profile and evolution of GEMM tumors is necessary. Here, we performed whole-exome sequencing of tumors from three GEMMs of...
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