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Article

FoxP3 interacts with linker histone H1.5 to modulate gene expression and program Treg cell activity.

Genes and immunity - 1 Oct 2011

Mackey-Cushman S L, Gao J, Holmes D A, Nunoya J-i, Wang R, Unutmaz D, Su L

Abstract excerpt

The forkhead box transcription factor FoxP3 controls the development and function of CD4+CD25+ regulatory T (Treg) cell. FoxP3 modulates gene expression in Treg cells by multiple epigenetic mechanisms that are not clearly defined. We identified FoxP3-interacting proteins in human T cells by co-immunoprecipitation/MS. We discovered that FoxP3 interacted with linker histone H1.5 via the leucine zipper (LZ) domain....

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Identifiers

PMID: 21654845
DOI: 10.1038/gene.2011.31
PMCID: PMC4329728

Genes

CTLA4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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