Article
FOXP3 orchestrates H4K16 acetylation and H3K4 trimethylation for activation of multiple genes by recruiting MOF and causing displacement of PLU-1.
Molecular cell - 9 Dec 2011
Katoh Hiroto, Qin Zhaohui S, Liu Runhua, Wang Lizhong, Li Weiquan, Li Xiangzhi, Wu Lipeng, Du Zhanwen, Lyons Robert, Liu Chang-Gong, Liu Xiuping, Dou Yali, Zheng Pan, Liu Yang
Abstract excerpt
Both H4K16 acetylation and H3K4 trimethylation are required for gene activation. However, it is still largely unclear how these modifications are orchestrated by transcriptional factors. Here, we analyzed the mechanism of the transcriptional activation by FOXP3, an X-linked suppressor of autoimmune diseases and cancers. FOXP3 binds near transcriptional start sites of its target genes. By recruiting MOF and...
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