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Article

Two lysines in the forkhead domain of foxp3 are key to T regulatory cell function.

PloS one - 1 Jan 2012

Liu Yujie, Wang Liqing, Han Rongxiang, Beier Ulf H, Hancock Wayne W

Abstract excerpt

BACKGROUND: The forkhead box transcription factor, Foxp3, is master regulator of the development and function of CD4+CD25+ T regulatory (Treg) cells that limit autoimmunity and maintain immune homeostasis. The carboxyl-terminal forkhead (FKH) domain is required for the nuclear localization and DNA binding of Foxp3. We assessed how individual FKH lysines contribute to the functions of Foxp3 in Treg cells....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22247766
DOI: 10.1371/journal.pone.0029035
PMCID: PMC3256141

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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