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Article

Analysis of FOXP3 reveals multiple domains required for its function as a transcriptional repressor.

Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2006

Lopes Jared E, Torgerson Troy R, Schubert Lisa A, Anover Stephanie D, Ocheltree Elizabeth L, Ochs Hans D, Ziegler Steven F

Abstract excerpt

Foxp3 has been shown to be both necessary and sufficient for the development and function of naturally arising CD4+ CD25+ regulatory T cells in mice. Mutation of Foxp3 in Scurfy mice and FOXP3 in humans with IPEX results in fatal, early onset autoimmune disease and demonstrates the critical role of FOXP3 in maintaining immune homeostasis. The FOXP3 protein encodes several functional domains, including a C2H2 zinc...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16920951
DOI: 10.4049/jimmunol.177.5.3133

Genes

FOXP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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