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Article

Molecular and biological role of the FOXP3 N-terminal domain in immune regulation by T regulatory/suppressor cells.

Experimental and molecular pathology - 1 Dec 2012

Deng Guoping, Xiao Yan, Zhou Zhaocai, Nagai Yasuhiro, Zhang Hongtao, Li Bin, Greene Mark I

Abstract excerpt

Regulatory T (Treg) cells are essential in preventing the host from developing certain autoimmune diseases and limiting excessive immune responses against pathogens. The normal function of most Treg cells requires sustained expression of functional FOXP3, a member of the FOXP family transcription factors. FOXP3 is distinct from other subfamily members because of its unique proline rich amino (N)-terminal domain....

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Identifiers

PMID: 23041265
DOI: 10.1016/j.yexmp.2012.09.013
PMCID: PMC3518637

Genes

FOXP3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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