Article

Human NOP2/NSUN1 Regulates Ribosome Biogenesis Through Non-Catalytic Complex Formation with Box C/D snoRNPs

2021-11-13

Abstract excerpt

<h4>ABSTRACT</h4> 5-Methylcytosine (m 5 C) is a base modification broadly found on various RNAs in the human transcriptome. In eukaryotes, m 5 C is catalyzed by enzymes of the NSUN family composed of seven human members (NSUN1-7). NOP2/NSUN1 has been primarily characterized in budding yeast as an essential ribosome biogenesis factor required for the deposition of m 5 C on the 25S ribosomal RNA (rRNA). Although...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c1ccf8ef-d543-595c-b0c1-b0c027ce030e
DOI: 10.1101/2021.11.12.468419

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human NOP2/NSUN1 Regulates Ribosome Biogenesis Through Non-Catalytic Complex Formation with Box C/D snoRNPsDOI 10.1101/2021.11.12.468419Read

snoRNA-guided tRNA 2’-O-methylation controls codon-biased gene expression and cellular statesSemantic proximity Read

Sequence- and structure-specific cytosine-5 mRNA methylation by NSUN6Semantic proximity Read

Yeast Nop2 and Rcm1 methylate C2870 and C2278 of the 25S rRNA, respectively.Semantic proximity Read

Multiple links between 5-methylcytosine content of mRNA and translationSemantic proximity Read

Molecular basis of tRNA modification by the human m <sup>5</sup> C methyltransferase NSUN2Semantic proximity Read

High-throughput identification of C/D box snoRNA targets with CLIP and RiboMeth-seqSemantic proximity Read

Systematic identification of tissue-conserved m <sup>6</sup> A sites reveals a stable epitranscriptomic regulatory layer controlling essential genesSemantic proximity Read

The snoGloBe interaction predictor reveals a broad spectrum of C/D snoRNA RNA targetsSemantic proximity Read

U1 snRNP-Specific U1C Acts as the Gatekeeper of the Survival of Motor Neurons (SMN) Complex in snRNP BiogenesisSemantic proximity Read

A late-stage assembly checkpoint of the human mitochondrial ribosome large subunitSemantic proximity Read

NSUN2 introduces 5-methylcytosines in mammalian mitochondrial tRNAsSemantic proximity Read

Systematic mapping of small nucleolar RNA targets in human cellsSemantic proximity Read