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Article

Spatial regulation of NSUN2-mediated tRNA m5C installation in cognitive function.

Nucleic acids research - 11 Jan 2025

Gonskikh Yulia, Tirrito Christian, Bommisetti Praneeth, Mendoza-Figueroa Maria Saraí, Stoute Julian, Kim Joshua, Wang Qin, Song Yuanquan, Liu Kathy Fange

Abstract excerpt

Enzyme-mediated modifications of tRNA, such as 5-methylcytosine (m5C) installed by nuclear-enriched NOP2/Sun RNA methyltransferase 2 (NSUN2), play a critical role in neuronal development and function. However, our understanding of these modifications' spatial installation and biological functions remains incomplete. In this study, we demonstrate that a nucleoplasm-localized G679R NSUN2 mutant, linked to...

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Identifiers

PMID: 39673800
DOI: 10.1093/nar/gkae1169
PMCID: PMC11754655

Genes

NSUN2
NOP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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