Article

Uncovering hidden gene-trait patterns through biclustering analysis of the UK Biobank

2024-11-11

Abstract excerpt

The growing availability of genome-wide association studies (GWAS) and large-scale biobanks provides an unprecedented opportunity to explore the genetic basis of complex traits and diseases. However, with this vast amount of data comes the challenge of interpreting numerous associations across thousands of traits, especially given the high polygenicity and pleiotropy underlying complex phenotypes. Traditional clus...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6d349bb8-6ede-595a-8a4e-89149befc901
DOI: 10.1101/2024.11.08.622657

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Uncovering hidden gene-trait patterns through biclustering analysis of the UK BiobankDOI 10.1101/2024.11.08.622657Read

Systematic classification of shared components of genetic risk for common human diseasesSemantic proximity Read

A Bayesian network-based framework to uncover the causal effects of genes on complex traits based on GWAS dataSemantic proximity Read

A Bayesian network-based framework to uncover the causal effects of genes on complex traits based on GWAS dataSemantic proximity Read

Identifying cross-disease components of genetic risk across hospital data in the UK Biobank.Semantic proximity Read

Bayesian analysis of genetic association across tree-structured routine healthcare data in the UK BiobankSemantic proximity Read

Multitrait genetic-phenotype associations to connect disease variants and biological mechanismsSemantic proximity Read

mFABIO: An integrative multi-tissue TWAS fine-mapping approach to prioritize potentially causal genes and tissues underlying binary traits.Semantic proximity Read

A global atlas of genetic associations of 220 deep phenotypesSemantic proximity Read

Discerning asthma endotypes through comorbidity mapping.Semantic proximity Read

Multitrait GWAS to connect disease variants and biological mechanisms.Semantic proximity Read

PWAS Hub for exploring gene-based associations of common complex diseases.Semantic proximity Read

Allele-specific network reveals combinatorial interaction that transcends small effects in psoriasis GWAS.Semantic proximity Read