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Article

Allele-specific network reveals combinatorial interaction that transcends small effects in psoriasis GWAS.

PLoS computational biology - 1 Sept 2014

Climer Sharlee, Templeton Alan R, Zhang Weixiong

Abstract excerpt

Hundreds of genetic markers have shown associations with various complex diseases, yet the "missing heritability" remains alarmingly elusive. Combinatorial interactions may account for a substantial portion of this missing heritability, but their discoveries have been impeded by computational complexity and genetic heterogeneity. We present BlocBuster, a novel systems-level approach that efficiently constructs...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25233071
DOI: 10.1371/journal.pcbi.1003766
PMCID: PMC4168982

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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