Article

Systematic classification of shared components of genetic risk for common human diseases

2018-07-23

Abstract excerpt

Disease classification is fundamental to clinical practice, but current taxonomies do not necessarily reflect the pathophysiological processes that are common or unique to different disorders, such as those determined by genetic risk factors. Here, we use routine healthcare data from the 500,000 participants in the UK Biobank to map genome-wide associations across 19,628 diagnostic terms. We find that 3,510 indepe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 67bf2ea4-63c9-5fb5-8d42-25dd43ca99df
DOI: 10.1101/374207

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Systematic classification of shared components of genetic risk for common human diseasesDOI 10.1101/374207Read

Identifying cross-disease components of genetic risk across hospital data in the UK Biobank.Semantic proximity Read

A global overview of genetically interpretable multimorbidities among common diseases in the UK Biobank.Semantic proximity Read

Phenome-wide association network demonstrates close connection with individual disease trajectories from the HUNT study.Semantic proximity Read

A global overview of genetically interpretable comorbidities among common diseases in UK BiobankSemantic proximity Read

The high-dimensional space of human diseases built from diagnosis records and mapped to genetic loci.Semantic proximity Read

Phenome-wide association network demonstrates close connection with individual disease trajectories from the HUNT studySemantic proximity Read

Towards a complete resolution of the genetic architecture of disease.Semantic proximity Read

A framework for integrated clinical risk assessment using population sequencing dataSemantic proximity Read

Phenome-wide association network demonstrates close connection with individual disease trajectories from the HUNT studySemantic proximity Read

Genome-wide polygenic score to identify a monogenic risk-equivalent for coronary diseaseSemantic proximity Read

Disease clusters subsequent to anxiety and stress-related disorders and their genetic determinants.Semantic proximity Read

The multiplex network of human diseasesSemantic proximity Read