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Article

mFABIO: An integrative multi-tissue TWAS fine-mapping approach to prioritize potentially causal genes and tissues underlying binary traits.

PLoS genetics - 1 May 2026

Zhang Haihan, He Kevin, Tsoi Lam C, Zhou Xiang

Abstract excerpt

Recent advances in transcriptome-wide association study (TWAS) fine-mapping have enabled the joint modeling of multiple genes to improve causal gene prioritization. However, existing methods have been developed primarily for quantitative traits and most of them rely on gene expression data from a single tissue. Here, we present mFABIO, a multi-tissue TWAS fine-mapping method specifically designed for binary...

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Identifiers

PMID: 42201988
DOI: 10.1371/journal.pgen.1012157
PMCID: PMC13225670

Genes

CCR6
CYBRD1
D2HGDH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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