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Article

PWAS Hub for exploring gene-based associations of common complex diseases.

Genome research - 29 Oct 2024

Kelman Guy, Zucker Roei, Brandes Nadav, Linial Michal

Abstract excerpt

PWAS (proteome-wide association study) is an innovative genetic association approach that complements widely used methods like GWAS (genome-wide association study). The PWAS approach involves consecutive phases. Initially, machine learning modeling and probabilistic considerations quantify the impact of genetic variants on protein-coding genes' biochemical functions. Secondly, for each individual, aggregating the...

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PMID: 39406500
DOI: 10.1101/gr.278916.123
PMCID: PMC11529988

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