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Article

Multitrait GWAS to connect disease variants and biological mechanisms.

PLoS genetics - 1 Aug 2021

Julienne Hanna, Laville Vincent, McCaw Zachary R, He Zihuai, Guillemot Vincent, Lasry Carla, Ziyatdinov Andrey, Nerin Cyril, Vaysse Amaury, Lechat Pierre, Ménager Hervé, Le Goff Wilfried, Dube Marie-Pierre, Kraft Peter, Ionita-Laza Iuliana, Vilhjálmsson Bjarni J, Aschard Hugues

Abstract excerpt

Genome-wide association studies (GWASs) have uncovered a wealth of associations between common variants and human phenotypes. Here, we present an integrative analysis of GWAS summary statistics from 36 phenotypes to decipher multitrait genetic architecture and its link with biological mechanisms. Our framework incorporates multitrait association mapping along with an investigation of the breakdown of genetic...

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Identifiers

PMID: 34460823
DOI: 10.1371/journal.pgen.1009713
PMCID: PMC8437297

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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