Article

A global atlas of genetic associations of 220 deep phenotypes

2020-10-27

Abstract excerpt

Current genome-wide association studies (GWASs) do not yet capture sufficient diversity in populations and scope of phenotypes. To expand an atlas of genetic associations in non-European populations, we conducted 220 deep-phenotype GWASs (diseases, biomarkers, and medication usage) in BioBank Japan ( n =179,000), by incorporating past medical history and text-mining of electronic medical records. Meta-analyses wit...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 826bcc85-afa3-5422-9c44-d520175fa7ca
DOI: 10.1101/2020.10.23.20213652

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A global atlas of genetic associations of 220 deep phenotypesDOI 10.1101/2020.10.23.20213652Read

A cross-population atlas of genetic associations for 220 human phenotypes.Semantic proximity Read

Large-scale meta-analysis of over one million individuals reveals the genetic architecture of 127 complex traits in East Asian populationsSemantic proximity Read

Leveraging deep phenotyping from health check-up cohort with 10,000 Korean individuals for phenome-wide association study of 136 traits.Semantic proximity Read

Systematic classification of shared components of genetic risk for common human diseasesSemantic proximity Read

Phenome-wide search for pleiotropic loci highlights key genes and molecular pathways for human complex traitsSemantic proximity Read

Joint analysis reveals shared autoimmune disease associations and identifies common mechanismsSemantic proximity Read

Global Biobank Meta-analysis Initiative: powering genetic discovery across human diseasesSemantic proximity Read

A catalog of GWAS fine-mapping efforts in autoimmune diseaseSemantic proximity Read

Analysis across Taiwan Biobank, Biobank Japan and UK Biobank identifies hundreds of novel loci for 36 quantitative traitsSemantic proximity Read

A survey of genome-wide association studies, polygenic scores and UK Biobank highlights resources for autoimmune disease genetics.Semantic proximity Read

Genome-Wide Assessment of Pleiotropy Across >1000 Traits from Global BiobanksSemantic proximity Read

Genetic Profiling of Autoimmune Diseases and Exploring Clusters Through Polygenic Risk Score Analysis Using Cohort Data from the UK BiobankSemantic proximity Read