Article
Discerning asthma endotypes through comorbidity mapping.
Nature communications - 7 Nov 2022
Jia Gengjie, Zhong Xue, Im Hae Kyung, Schoettler Nathan, Pividori Milton, Hogarth D Kyle, Sperling Anne I, White Steven R, Naureckas Edward T, Lyttle Christopher S, Terao Chikashi, Kamatani Yoichiro, Akiyama Masato, Matsuda Koichi, Kubo Michiaki, Cox Nancy J, Ober Carole, Rzhetsky Andrey, Solway Julian
Abstract excerpt
Asthma is a heterogeneous, complex syndrome, and identifying asthma endotypes has been challenging. We hypothesize that distinct endotypes of asthma arise in disparate genetic variation and life-time environmental exposure backgrounds, and that disease comorbidity patterns serve as a surrogate for such genetic and exposure variations. Here, we computationally discover 22 distinct comorbid disease patterns among...
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