Article
Baculovirus protein PK2 subverts eIF2α kinase function by mimicry of its kinase domain C-lobe.
Proceedings of the National Academy of Sciences of the United States of America - 11 Aug 2015
Li John J, Cao Chune, Fixsen Sarah M, Young Janet M, Ono Chikako, Bando Hisanori, Elde Nels C, Katsuma Susumu, Dever Thomas E, Sicheri Frank
Abstract excerpt
Phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) by eIF2α family kinases is a conserved mechanism to limit protein synthesis under specific stress conditions. The baculovirus-encoded protein PK2 inhibits eIF2α family kinases in vivo, thereby increasing viral fitness. However, the precise mechanism by which PK2 inhibits eIF2α kinase function remains an enigma. Here, we probed the mechanism by...
Topics
- Animals
- Baculoviridae
- Bombyx
- Cell Line
- DNA Mutational Analysis
- Models, Molecular
- Molecular Mimicry
- Mutation
- Protein Binding
- Protein Structure, Tertiary