Article

Accelerated selection of a viral RNA polymerase variant during gene copy number amplification promotes rapid evolution of vaccinia virus

2016-08-01

Abstract excerpt

Viruses are under relentless selective pressure from host immune defenses. To study how poxviruses adapt to innate immune detection pathways, we performed serial infections of vaccinia virus in primary human cells. Independent courses of experimental evolution with a recombinant strain lacking E3L revealed several high frequency point mutations in conserved poxvirus genes, suggesting important roles for essential...

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Literature Corpus work: 02f1b71a-7a04-5bc3-ba1f-28a8611fb330
DOI: 10.1101/066845

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