Article

A functional map of CDK-drug interactions at single amino acid resolution

2025-11-03

Abstract excerpt

Proteins that drive or support human disease phenotypes are attractive molecular targets for precision therapy, yet most are nominated by knockout studies and then targeted with drugs that inhibit core catalytic pockets. These strategies cannot resolve which residues are essential, whether non-catalytic sites offer better selectivity or potency, or identify on-target resistance mechanisms. We introduce a framework...

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Literature Corpus work: 9926dfeb-2daa-5e21-8dce-891b63506463
DOI: 10.1101/2025.11.02.685764

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