Article

Selection for Decreased BRCA2 Functional Activity in <i>Homo sapiens</i> After Divergence from the Chimpanzee-Human Last Common Ancestor

2020-11-16

Abstract excerpt

Humans have an increased incidence of epithelial neoplasia compared to non-human primates. We performed a comparative analysis of 21 non-human primate genomes and 54 ancient human genomes to identify variations in known cancer genes that may explain this difference. We identified 299 human-specific fixed non-silent single nucleotide polymorphisms. Bioinformatics analyses for functional consequences identified a nu...

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Literature Corpus work: 6d097078-58be-531e-8d8b-29b3bea9d1e0
DOI: 10.1101/2020.11.16.384677

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