Article

Selective pressures on human cancer genes along the evolution of mammals

2018-08-09

Abstract excerpt

Cancer is a disease of the genome caused by somatic mutation and subsequent clonal selection. Several genes associated to cancer in humans, hereafter cancer genes, also show evidence of (germline) positive selection among species. Taking advantage of a large collection of mammalian genomes, we systematically looked for statistically significant signatures of positive selection using dN/dS models in a list of 430...

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Literature Corpus work: 0709d390-8627-568a-8a9f-fc1b78972c98
DOI: 10.1101/388421

Open publication

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