Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Natural selection and mammalian BRCA1 sequences: elucidating functionally important sites relevant to breast cancer susceptibility in humans.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Mar 2006

Burk-Herrick Angela, Scally Mark, Amrine-Madsen Heather, Stanhope Michael J, Springer Mark S

Abstract excerpt

Comparison of orthologous gene sequences is emerging as a powerful approach to elucidating functionally important positions in human disease genes. Using a diverse array of 132 mammalian BRCA1 (exon 11) sequences, we evaluated the functional significance of specific sites in the context of selection information (purifying, neutral, or diversifying) as well as the ability to extract such information from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA1 Protein
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Evolution, Molecular

Share to Genetic Predisposition to Disease

Share to Mammals

Share to Mutation, Missense

Share to Phylogeny

Share to Selection, Genetic

Source

Identifiers

PMID: 16518693
DOI: 10.1007/s00335-005-0067-2

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Natural selection and mammalian BRCA1 sequences: elucidating functionally important sites relevant to breast cancer susceptibility in humans.PMID 16518693Read ↗

Evolution of the tumor suppressor BRCA1 locus in primates: implications for cancer predisposition.Semantic proximity Read ↗

Bioinformatics Approaches to Explore the Phylogeny and Role of BRCA1 in Breast Cancer.Semantic proximity Read ↗

Evidence for reduced BRCA2 functional activity in Homo sapiens after divergence from the chimpanzee-human last common ancestor.Semantic proximity Read ↗

Rapid evolution of BRCA1 and BRCA2 in humans and other primates.Semantic proximity Read ↗

Human BRCA pathogenic variants were originated during recent human history.Semantic proximity Read ↗

A systematic genetic assessment of 1,433 sequence variants of unknown clinical significance in the BRCA1 and BRCA2 breast cancer-predisposition genes.Semantic proximity Read ↗

The molecular evolution of cancer associated genes in mammals.Semantic proximity Read ↗

Selective pressures on human cancer genes along the evolution of mammalsSemantic proximity Read ↗

When Two plus Four Does Not Equal Six: Combining Computational and Functional Evidence to Classify BRCA1 Key Domain Missense Substitutions.Semantic proximity Read ↗

Selection for Decreased BRCA2 Functional Activity in <i>Homo sapiens</i> After Divergence from the Chimpanzee-Human Last Common AncestorSemantic proximity Read ↗

Adaptive evolution of the tumour suppressor BRCA1 in humans and chimpanzees. Australian Breast Cancer Family Study.Semantic proximity Read ↗

Missense mutations in the BRCT domain of BRCA-1 from high-risk women frequently perturb strongly hydrophobic amino acids conserved among mammals.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.