Article
Evolution of the tumor suppressor BRCA1 locus in primates: implications for cancer predisposition.
Human molecular genetics - 15 Nov 2004
Pavlicek Adam, Noskov Vladimir N, Kouprina Natalay, Barrett J Carl, Jurka Jerzy, Larionov Vladimir
Abstract excerpt
Germ-line mutations in the BRCA1 gene predispose affected individuals to breast and ovarian cancer syndromes. In an attempt to systematically analyze a broader spectrum of genetic changes ranging from frequent exon deletions and duplications to amino acid replacements and protein truncations, we isolated and characterized full size BRCA1 homologues from a representative group of non-human primates. Our analysis...
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