Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identifying functional genetic variants in DNA repair pathway using protein conservation analysis.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 May 2004

Savas Sevtap, Kim David Y, Ahmad M Farhan, Shariff Mehjabeen, Ozcelik Hilmi

Abstract excerpt

The role of DNA repair in initiation, promotion, and progression of malignancy suggests that variations in DNA repair genes confer altered cancer risk. Accordingly, DNA repair gene variants have been studied extensively in the context of cancer predisposition. Single nucleotide polymorphisms (SNPs) are the most common genetic variations in the human genome. A fraction of SNPs are located within the genes, which...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA-Binding Proteins
Share to DNA, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair

Share to Neoplasms

Share to Predictive Value of Tests

Share to Protein Conformation

Share to Risk Assessment

Share to Sensitivity and Specificity

Source

Identifiers

PMID: 15159313

Genes

XRCC1
XRCC3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identifying functional genetic variants in DNA repair pathway using protein conservation analysis.PMID 15159313Read ↗

Computational prediction of the effects of non-synonymous single nucleotide polymorphisms in human DNA repair genes.Semantic proximity Read ↗

Single nucleotide polymorphisms in DNA repair genes and putative cancer risk.Semantic proximity Read ↗

Genetic variants of the DNA repair genes from Exome Aggregation Consortium (EXAC) database: significance in cancer.Semantic proximity Read ↗

Identification of 127 amino acid substitution variants in screening 37 DNA repair genes in humans.Semantic proximity Read ↗

Functional nsSNPs from carcinogenesis-related genes expressed in breast tissue: potential breast cancer risk alleles and their distribution across human populations.Semantic proximity Read ↗

Computational refinement of functional single nucleotide polymorphisms associated with ATM gene.Semantic proximity Read ↗

An evolutionary perspective on single-nucleotide polymorphism screening in molecular cancer epidemiology.Semantic proximity Read ↗

Applications of computational algorithm tools to identify functional SNPs.Semantic proximity Read ↗

Approaches and resources for prediction of the effects of non-synonymous single nucleotide polymorphism on protein function and interactions.Semantic proximity Read ↗

Functional Polymorphisms in DNA Repair Genes Are Associated with Sporadic Colorectal Cancer Susceptibility and Clinical OutcomeSemantic proximity Read ↗

Pathogenic nsSNPs that increase the risks of cancers among the Orang Asli and Malays.Semantic proximity Read ↗

A computational approach to determine susceptibility to cancer by evaluating the deleterious effect of nsSNP in XRCC1 gene on binding interaction of XRCC1 protein with ligase III.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.