Article
Adaptive evolution of the tumour suppressor BRCA1 in humans and chimpanzees. Australian Breast Cancer Family Study.
Nature genetics - 1 Aug 2000
Huttley G A, Easteal S, Southey M C, Tesoriero A, Giles G G, McCredie M R, Hopper J L, Venter D J
Abstract excerpt
Mutations in BRCA1 (ref. 1) confer an increased risk of female breast cancer. In a genome-wide scan of linkage disequilibrium (LD), a high level of LD was detected among microsatellite markers flanking BRCA1 (ref. 3), raising the prospect that positive natural selection may have acted on this gene. We have used the predictions of evolutionary genetic theory to investigate this further. Using phylogeny-based...
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