Mutational spectrum in the recent human genome inferred by single nucleotide polymorphisms.

doi:10.1016/j.ygeno.2006.06.003

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Article

Mutational spectrum in the recent human genome inferred by single nucleotide polymorphisms.

Genomics - 1 Nov 2006

Jiang Cizhong, Zhao Zhongming

Abstract excerpt

So far, there is no genome-wide estimation of the mutational spectrum in humans. In this study, we systematically examined the directionality of the point mutations and maintenance of GC content in the human genome using approximately 1.8 million high-quality human single nucleotide polymorphisms and their ancestral sequences in chimpanzees. The frequency of C-->T (G-->A) changes was the highest among all...

Topics

Animals
Base Composition
Biometry
CpG Islands
DNA
Data Interpretation, Statistical
Databases, Nucleic Acid
Evolution, Molecular
Exons
Genome, Human
Genomics
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Introns

Mutation

Pan troglodytes

Papio

Point Mutation

Polymorphism, Single Nucleotide

Source

Open in PubMed

Identifiers

PMID: 16860534
DOI: 10.1016/j.ygeno.2006.06.003

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