Article
Analyses of a Mutant Foxp3 Allele Reveal BATF as a Critical Transcription Factor in the Differentiation and Accumulation of Tissue Regulatory T Cells.
Immunity - 15 Aug 2017
Hayatsu Norihito, Miyao Takahisa, Tachibana Masashi, Murakami Ryuichi, Kimura Akihiko, Kato Takako, Kawakami Eiryo, Endo Takaho A, Setoguchi Ruka, Watarai Hiroshi, Nishikawa Takeshi, Yasuda Takuwa, Yoshida Hisahiro, Hori Shohei
Abstract excerpt
Foxp3 controls the development and function of regulatory T (Treg) cells, but it remains elusive how Foxp3 functions in vivo. Here, we established mouse models harboring three unique missense Foxp3 mutations that were identified in patients with the autoimmune disease IPEX. The I363V and R397W mutations were loss-of-function mutations, causing multi-organ inflammation by globally compromising Treg cell...
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