Article

T cell phenotyping of a mouse model of Activated PI3Kdelta Syndrome

2019-01-01

Abstract excerpt

Activated PI3Kdelta Syndrome (APDS) is immunodeficiency caused by a heterozygous gain-of-function mutation (E1021K) in the PIK3CD gene, encoding for the p110delta catalytic subunit of phosphoinositide 3-kinase (PI3K). APDS patients are lymphopenic, suffer from sinopulmonary infections and from increased susceptibility to bacterial and herpes group virus infections. Following T cell receptor (TCR) stimulation, T ce...

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Literature Corpus work: 4884acd1-9959-5887-933a-b6690c5121e3
DOI: 10.17863/cam.40724

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