Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activated PIK3CD drives innate B cell expansion yet limits B cell–intrinsic immune responses

7 Sept 2018

Abstract excerpt

Activated PI3K-delta syndrome (APDS) is an immunodeficiency caused by gain-of-function mutations in PIK3CD. This disease exhibits complex immune phenotypes including increased IgM, recurrent infection, and impaired vaccine responses. To better understand the impact of B cells in this disease, we generated an inducible model of the common APDS mutation (hPIK3CD-E1021K; referred to as aPIK3CD) and intercrossed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chronic Lymphocytic Leukemia Research
Share to Immune Cell Function and Interaction
Share to Immunodeficiency and Autoimmune Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30194267
DOI: 10.1084/jem.20180617

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activated PIK3CD drives innate B cell expansion yet limits B cell–intrinsic immune responsesPMID 30194267Read ↗

Germline-activating mutations in PIK3CD compromise B cell development and function.Semantic proximity Read ↗

Cellular Mechanisms Underlying B Cell Abnormalities in Patients With Gain-of-Function Mutations in the PIK3CD Gene.Semantic proximity Read ↗

Human PIK3R1 mutations disrupt lymphocyte differentiation to cause activated PI3Kδ syndrome 2.Semantic proximity Read ↗

Both T and B cells contribute to dysregulated activation and differentiation of CD4 <sup>+</sup> T cells in Activated PI3K delta syndrome 1Semantic proximity Read ↗

Hyperactivated PI3Kδ promotes self and commensal reactivity at the expense of optimal humoral immunity.Semantic proximity Read ↗

Genetic defects in PI3Kδ affect B-cell differentiation and maturation leading to hypogammaglobulineamia and recurrent infections.Semantic proximity Read ↗

Hyperactivation of the PI3K pathway in inborn errors of immunity: current understanding and therapeutic perspectivesSemantic proximity Read ↗

Homozygous Loss of Function PIK3CD Mutation in Multiple Siblings Leading To B Cell Dysregulation and Autoimmunity.Semantic proximity Read ↗

Activated PI3Kinase Delta Syndrome—A Multifaceted DiseaseSemantic proximity Read ↗

PI3Kδ and primary immunodeficiencies.Semantic proximity Read ↗

Disorders Related to PI3Kδ Hyperactivation: Characterizing the Clinical and Immunological Features of Activated PI3-Kinase Delta SyndromesSemantic proximity Read ↗

Genetic Defects in Phosphoinositide 3-Kinase δ Influence CD8+ T Cell Survival, Differentiation, and Function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.